Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Xin Liu; Lili An; Yonghui Zhou; Wei Peng; Cong Huang

doi:10.2147/IDR.S398227

Antibacterial Mechanism of Patrinia scabiosaefolia Against Methicillin Resistant Staphylococcus epidermidis

Infect Drug Resist. 2023 Mar 10:16:1345-1355. doi: 10.2147/IDR.S398227. eCollection 2023.

Authors

Xin Liu¹, Lili An², Yonghui Zhou¹, Wei Peng¹, Cong Huang¹

Affiliations

¹ College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang City, People's Republic of China.
² Dermatology Department, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang City, People's Republic of China.

Abstract

Purpose: Staphylococcus epidermidis has become one of the most common causes of septicemia. Meanwhile, S. epidermidis has acquired resistance to many antibiotics. Among these, methicillin-resistant S. epidermidis (MRSE) were frequently isolated. Similar to methicillin resistant Staphylococcus aureus (MRSA), they also exhibited multi-resistance, which presented a danger to human health. Patrinia scabiosaefolia as traditional Chinese medicine had strong antibacterial activity against MRSE. However, the mechanism of P. scabiosaefolia against MRSE is not clear.

Methods: Here, the morphology of cell wall and cell membrane, production of β-lactamase and PBP2, energy metabolism, antioxidant system were systematically studied.

Results: The data showed that P. scabiosaefolia damaged the cell wall and membrane. In addition, β-lactamase, energy metabolism and antioxidant system were involved in mechanisms of P. scabiosaefolia against MRSE.

Conclusion: These observations provided new understanding of P. scabiosaefolia against MRSE to control MRSE infections.

Keywords: Patrinia scabiosifolia; antioxidant system; energy metabolism; methicillin-resistantStaphylococcus epidermidis; β-lactamase.

Grants and funding

The National Nature Science Foundation of China under Grant number 82260824. The Science and Technology Foundation of Guizhou Province under Grant number Qianke He Foundation-ZK (2021) General 08. The Young scientific and technological talents project of Gui Zhou Department of Education under Grant number Qianjiaohe KY (2022) 269. The Gui Zhong Yi Ke Yuan Nei (2013) 22#.