Predictive value of hyperglycemia on prognosis in spontaneous intracerebral hemorrhage patients

Yue Gong; Yifei Wang; Du Chen; Yue Teng; Feng Xu; Peng Yang

doi:10.1016/j.heliyon.2023.e14290

Predictive value of hyperglycemia on prognosis in spontaneous intracerebral hemorrhage patients

Heliyon. 2023 Mar 8;9(3):e14290. doi: 10.1016/j.heliyon.2023.e14290. eCollection 2023 Mar.

Authors

Yue Gong¹, Yifei Wang¹, Du Chen¹, Yue Teng¹, Feng Xu¹, Peng Yang¹

Affiliation

¹ First Affiliated Hospital of Soochow University, China.

Abstract

Background: Spontaneous intracerebral hemorrhage (ICH) is the second most common cause of stroke and accounts for approximately 15-20% of all new stroke cases. Hematoma expansion is a potentially important therapeutic target that is amenable to treatment and independently predict outcome. Hyperglycemia is frequent in ICH patients, and affects cerebrovascular function, increasing the risk of cerebral vascular rupture. We recruited 170 ICH patients to explore the high risk factors of mortality and the association between hyperglycemia and early hematoma expansion.

Methods: A retrospective analysis of 170 patients with ICH who were grouped by survival and blood glucose level, death group (35 cases) and survival group (135 cases); 77 cases in the hyperglycemic group and 93 cases in the normoglycemic group. Recorded parameters, such as age, gender, past medical history, blood glucose, serum calcium, hematoma volume, and hematoma expansion. Group comparison used t-test, rank sum test and Fisher exact test. After these, logistic regression analysis and receiver operating characteristic (ROC) curves were performed.

Results: Among 170 ICH subjects(130 males and 40 females)，35 died and 77 exhibited hyperglycaemia. Compared with the survival group, the death group presented with higher Original Intracerebral Hemorrhage Scale (OICH) score, greater blood glucose, larger hemorrhage volume and lower Glasgow Coma Scale (GCS) score. The occurrence of hematoma expansion and massive hemorrhage volume in the hyperglycemic group were higher than in the normoglycemic group(P < 0.05). After adjustment for confounders variables, multivariate logistic analysis showed that blood glucose was an independent predictor of hematoma expansion (adjusted odd ratio:8.04, 95%CI:3.89-16.63, P < 0.01). Fasting blood glucose had better predictive value for hematoma expansion (AUC:0.95, 95%CI:0.92-0.99, P < 0.01).

Conclusion: Hyperglycemia is associated with higher mortality risk and could be a potential marker in the prediction of hematoma expansion.

Keywords: Hematoma expansion; Hyperglycemia; Prognosis; Rebleeding; Spontaneous intracerebral hemorrhage.