Novel insights into central compartment atopic disease - a literature review

Weifeng Kong; Qingwu Wu; He Zhang; Yana Zhang; Qintai Yang

doi:10.1080/1744666X.2023.2192480

Novel insights into central compartment atopic disease - a literature review

Expert Rev Clin Immunol. 2023 Jul-Dec;19(8):847-856. doi: 10.1080/1744666X.2023.2192480. Epub 2023 Mar 21.

Authors

Weifeng Kong¹, Qingwu Wu¹, He Zhang¹, Yana Zhang^{1

2}, Qintai Yang^{1

2}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
² Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

PMID: 36924000
DOI: 10.1080/1744666X.2023.2192480

Abstract

Introduction: Central compartment atopic disease (CCAD) is a newly recognized variant subtype of chronic rhinosinusitis (CRS). Although CCAD has been reported to be correlated with allergy, there is still a considerable gap in our knowledge regarding CCAD.

Areas covered: We have conducted a thorough analysis of the literature on CCAD. This review provides current understanding and therapeutic strategies of CCAD. In this article, we will review the clinical presentations and parameters, allergy-related etiology, endotypes, and recommended management of CCAD.

Expert opinion: CCAD is considered as an aeroallergen-driven type 2/eosinophilic inflammatory pattern. Although CCAD can be diagnosed by endoscopy and radiology, as well as allergen test, pathogenesis and management strategies leave much to be desired, and further studies are needed.

Keywords: Allergy; biologics; central compartment atopic disease; chronic rhinosinusitis; endotypes.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Chronic Disease
Humans
Hypersensitivity* / therapy
Rhinitis* / pathology
Sinusitis* / pathology
Sinusitis* / therapy