MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan

Sadia Mahmood; Amna Younus; Sammar Nathaniel; Hooria Younas

doi:10.1080/10641955.2023.2187621

MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan

Hypertens Pregnancy. 2023 Dec;42(1):2187621. doi: 10.1080/10641955.2023.2187621.

Authors

Sadia Mahmood¹, Amna Younus¹, Sammar Nathaniel¹, Hooria Younas¹

Affiliation

¹ Department of Biochemistry, Kinnaird College for Women, Lahore, Pakistan.

PMID: 36922394
DOI: 10.1080/10641955.2023.2187621

Abstract

Objectives: This study aimed to investigate the genetic association between MTHFR (A1298C) SNP and preeclampsia (PE) in Punjab, Pakistan.

Methods: A sample of 80 pregnant women (40 healthy pregnant women and 40 with PE) was pooled for genotyping MTHFR A1298C polymorphism by using the tetra-primer amplification refractory mutation system (ARMS) PCR. The Genotypic and allelic assessments were performed using various statistical techniques.

Results: The AC genotype and C allele of MTHFR A1298C were found to be associated with decreased risk of PE (odds ratio [OR]: 0.31, risk ratio [RR]: 0.58, p = 0.01), and (odds ratio [OR]: 0.49, risk ratio [RR]: 0.61, p = 0.04), respectively.

Conclusion: In conclusion, genetic polymorphism A1298C in MTHFR may pose a protective effect in the studied population.

Keywords: MTHFR; polymorphism; preeclampsia.

MeSH terms

Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Methylenetetrahydrofolate Reductase (NADPH2)* / genetics
Pakistan
Polymorphism, Single Nucleotide*
Pre-Eclampsia* / genetics
Pregnancy

Substances

Methylenetetrahydrofolate Reductase (NADPH2)
MTHFR protein, human