OCT Emerging Technologies: Coronary Micro-optical Coherence Tomography

Kensuke Nishimiya; Radhika K Poduval; Guillermo J Tearney

doi:10.1016/j.iccl.2023.01.001

OCT Emerging Technologies: Coronary Micro-optical Coherence Tomography

Interv Cardiol Clin. 2023 Apr;12(2):237-244. doi: 10.1016/j.iccl.2023.01.001.

Authors

Kensuke Nishimiya¹, Radhika K Poduval², Guillermo J Tearney³

Affiliations

¹ Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan.
² Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
³ Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard-MIT Division of Health Sciences and Technology Division, Cambridge, MA, USA. Electronic address: gtearney@partners.org.

PMID: 36922064
DOI: 10.1016/j.iccl.2023.01.001

Abstract

Optical coherence tomography (OCT) is an imaging modality that is used in a significant number of interventional cardiology procedures. Key structural changes occurring within the vessel wall, including presence of neutrophils, macrophages, monocytes, and vascular smooth muscle cells, are below the resolution of clinical intracoronary OCT. To address this challenge, a new form of OCT with 1 to 2 μm resolution, termed micro-OCT (μOCT), has been developed. This review article summarizes the ability of μOCT technology to visualize coronary microstructures and discusses its clinical implications.

Keywords: Cholesterol crystals; Endothelial cells; Inflammatory cells; Macrophage; Micro-OCT (μOCT); Optical coherence tomography (OCT); Plaque erosion.

Publication types

Review

MeSH terms

Coronary Artery Disease*
Humans
Tomography, Optical Coherence* / methods