Update on nail unit histopathology

Rama Godse; Olaf Rodriguez; Katherine Omueti Ayoade; Adam I Rubin

doi:10.1016/j.humpath.2023.03.006

Update on nail unit histopathology

Hum Pathol. 2023 Oct:140:214-232. doi: 10.1016/j.humpath.2023.03.006. Epub 2023 Mar 13.

Authors

Rama Godse¹, Olaf Rodriguez², Katherine Omueti Ayoade², Adam I Rubin²

Affiliations

¹ Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Rama.Godse@pennmedicine.upenn.edu.
² Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

PMID: 36921726
DOI: 10.1016/j.humpath.2023.03.006

Abstract

Histopathologic evaluation of the nail unit is an essential component in the diagnosis of nail unit disorders. This review highlights recent updates in nail unit histopathology and discusses literature covering a wide range of nail disorders including melanoma/melanocytic lesions, squamous cell carcinoma, onychomatricoma, onychopapilloma, onychomycosis, lichen planus, and other inflammatory conditions. Herein we also discuss recent literature on nail clipping histopathology, a useful and noninvasive diagnostic tool that continues to grow in popularity and importance to both dermatologists and dermatopathologists.

Keywords: Inflammatory nail conditions; Nail clipping; Nail disorders; Nail pathology; Nail tumors; Nail unit; Nail unit histopathology.