Attempting to Unmask the Inhibition of Sulfotransferase 1E1 in 17α-Ethinyl Estradiol Drug Interactions

J Clin Pharmacol. 2023 Aug;63(8):875-879. doi: 10.1002/jcph.2235. Epub 2023 Apr 27.

Authors

David Rodrigues¹, Mark Niosi¹, Heather Eng¹, Christopher Healy¹, Sarah Lazzaro¹, Qingyi Yang², Matthew A Cerny¹

Affiliations

¹ Pharmacokinetics & Drug Metabolism, Medicine Design, Worldwide Research & Development, Pfizer Inc., Groton, Connecticut, USA.
² Computational Chemistry, Internal Medicine, Medicine Design, Worldwide Research & Development, Cambridge, Massachusetts, USA.

PMID: 36919596
DOI: 10.1002/jcph.2235

No abstract available

Keywords: 17α-ethinyl estradiol; drug interactions; oral contraceptives; sulfotransferase 1E1.

MeSH terms

Contraceptives, Oral, Combined*
Drug Interactions
Estradiol
Ethinyl Estradiol* / pharmacology
Female
Humans
Sulfotransferases

Substances

Ethinyl Estradiol
Contraceptives, Oral, Combined
Sulfotransferases
Estradiol