Spontaneous Cerebrospinal Fluid Rhinorrhea in a Patient With Breast Cancer

J Craniofac Surg. 2023 May 1;34(3):e304-e306. doi: 10.1097/SCS.0000000000009248. Epub 2023 Mar 15.

Abstract

Despite the well documented increased risk of osteopenia in patients with breast cancer during chemotherapy and endocrine therapy, spontaneous cerebrospinal fluid rhinorrhea (CSFR) is still rare. The authors present a case of spontaneous CSFR that occurred during chemotherapy and endocrine therapy for breast cancer. The patient underwent a repair using myofascia and adipose tissue and was started on mannitol. There was no recurrence at 1-year follow-up. Therefore, clinicians should pay attention to the possibility of CSFR in patients with breast cancer, to avoid misdiagnosis.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Hormonal* / adverse effects
  • Antineoplastic Agents, Hormonal* / therapeutic use
  • Bone Density* / drug effects
  • Breast Neoplasms* / drug therapy
  • Cerebrospinal Fluid Rhinorrhea* / chemically induced
  • Cerebrospinal Fluid Rhinorrhea* / diagnosis
  • Cerebrospinal Fluid Rhinorrhea* / surgery
  • Estrogen Antagonists* / adverse effects
  • Estrogen Antagonists* / therapeutic use
  • Female
  • Humans
  • Middle Aged
  • Sphenoid Sinus / diagnostic imaging
  • Sphenoid Sinus / pathology
  • Tamoxifen* / adverse effects
  • Tamoxifen* / therapeutic use
  • Tomography, X-Ray Computed

Substances

  • Tamoxifen
  • Estrogen Antagonists
  • Antineoplastic Agents, Hormonal