Acute tubulointerstitial nephritis with or without uveitis: a novel form of post-acute COVID-19 syndrome in children

Marina Avramescu; Pierre Isnard; Sarah Temmam; Agnès Chevalier; Paul Bastard; Mikael Attia; Romain Berthaud; Marc Fila; Claire Dossier; Julien Hogan; Tim Ulinski; Damia Leguevaques; Férielle Louillet; Edouard Martinez Casado; Jean-Michel Halimi; Sylvie Cloarec; Ariane Zaloszyc; Camille Faudeux; Caroline Rousset-Rouvière; Stéphanie Clavé; Jérôme Harambat; Edouard Rollot; Thomas Simon; Megan Nallet-Amate; Bruno Ranchin; Justine Bacchetta; Florence Porcheret; Josselin Bernard; Amélie Ryckewaert; Anne Jamet; Jacques Fourgeaud; Nicolas Da Rocha; Philippe Pérot; Nicolas Kuperwasser; Naïm Bouazza; Marion Rabant; Jean-Paul Duong Van Huyen; Matthieu P Robert; Julien Zuber; Jean-Laurent Casanova; Marc Eloit; Isabelle Sermet-Gaudelus; Olivia Boyer

doi:10.1016/j.kint.2023.02.028

Acute tubulointerstitial nephritis with or without uveitis: a novel form of post-acute COVID-19 syndrome in children

Kidney Int. 2023 Jun;103(6):1193-1198. doi: 10.1016/j.kint.2023.02.028. Epub 2023 Mar 12.

Authors

Marina Avramescu¹, Pierre Isnard², Sarah Temmam³, Agnès Chevalier⁴, Paul Bastard⁵, Mikael Attia⁶, Romain Berthaud¹, Marc Fila⁴, Claire Dossier⁷, Julien Hogan⁷, Tim Ulinski⁸, Damia Leguevaques⁹, Férielle Louillet¹⁰, Edouard Martinez Casado¹⁰, Jean-Michel Halimi¹¹, Sylvie Cloarec¹², Ariane Zaloszyc¹³, Camille Faudeux¹⁴, Caroline Rousset-Rouvière¹⁵, Stéphanie Clavé¹⁵, Jérôme Harambat¹⁶, Edouard Rollot¹⁶, Thomas Simon¹⁷, Megan Nallet-Amate¹⁸, Bruno Ranchin¹⁹, Justine Bacchetta¹⁹, Florence Porcheret²⁰, Josselin Bernard²⁰, Amélie Ryckewaert²¹, Anne Jamet²², Jacques Fourgeaud²², Nicolas Da Rocha³, Philippe Pérot³, Nicolas Kuperwasser²³, Naïm Bouazza²⁴, Marion Rabant²⁵, Jean-Paul Duong Van Huyen²⁵, Matthieu P Robert²⁶, Julien Zuber²⁷, Jean-Laurent Casanova²⁸, Marc Eloit³, Isabelle Sermet-Gaudelus²⁹, Olivia Boyer³⁰

Affiliations

¹ Pediatric Nephrology, Maladies REnales Héréditaires de l'Enfant et de l'Adulte (MARHEA) Reference Center, Institut National de la Santé Et de la Recherche Médicale (INSERM) U1163, Imagine Institute, Paris Cité University, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
² Department of Pathology, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France; Université de Paris, Institut National de la Santé Et de la Recherche Médicale (INSERM) U1151, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8253, Institut Necker Enfants Malades, Département « Croissance et Signalisation », Paris, France.
³ Pathogen Discovery Laboratory, Department of Virology, Institut Pasteur, Paris, France.
⁴ Department of Pediatric Nephrology, Arnaud-de-Villeneuve Hospital, University Hospital of Montpellier, Montpellier, France.
⁵ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé Et de la Recherche Médicale (INSERM) U1163, Imagine Institute, Necker-Enfants Malades Hospital, Paris, France; Paris Cité University, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA; Department of Pediatrics, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris, France.
⁶ Molecular Genetics of RNA Viruses, Department of Virology, Institut Pasteur, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 3569, Paris, France.
⁷ Department of Pediatric Nephrology, Robert Debré Hospital, Paris Cité University, Paris, France.
⁸ Department of Pediatric Nephrology, Armand Trousseau Hospital, Paris, France.
⁹ Department of Pediatric Nephrology, Centre Hospitalier Régional Universitaire (CHRU) de Lille, Lille, France.
¹⁰ Department of Pediatrics, Rouen University Hospital, Rouen, France.
¹¹ Department of Adult Nephrology, Centre Hospitalier Régional Universitaire (CHRU) de Tours, Tours, France.
¹² Department of Pediatric Nephrology, Clocheville Hospital, Centre Hospitalier Régional Universitaire (CHRU) de Tours, Tours, France.
¹³ Department of Pediatric Nephrology, centre Hospitalier Universitaire (CHU) de Strasbourg, Strasbourg, France.
¹⁴ Department of Pediatrics, Pediatric Nephrology Unit, L'Archet Hospital, University Hospital of Nice, Nice, France.
¹⁵ Department of Multidisciplinary Pediatrics, Pediatric Nephrology Unit, Assistance Publique - Hôpitaux de Marseille (APHM), Marseille, France.
¹⁶ Department of Pediatrics, Pediatric Nephrology Unit, SoRare Reference Center, Bordeaux University Hospital, Bordeaux, France.
¹⁷ Department of Pediatric Nephrology, SoRare Reference Center, Toulouse University Hospital, Toulouse, France.
¹⁸ Pediatric Department, Dijon University Hospital, Dijon, France.
¹⁹ Department of Pediatric Nephrology, centre Hospitalier Universitaire (CHU) de Lyon, Lyon, France.
²⁰ Pediatric Department, Nantes University Hospital, Nantes, France.
²¹ Department of Pediatric Nephrology, centre Hospitalier Universitaire (CHU) de Rennes, Rennes, France.
²² Department of Clinical Microbiology, Necker Enfants-Malades Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Paris Cité University, Paris, France.
²³ Paris Cité University, Institut National de la Santé Et de la Recherche Médicale (INSERM) U1151, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8253, Necker Enfants Malades Institute, Department « Croissance et Signalisation », Paris, France.
²⁴ Equipe Associée (EA) 7323, Université Paris, Pharmacologie et évaluations thérapeutiques chez l'enfant et la femme enceinte, Paris, France; Unité de Recherche Clinique, Hôpital Tarnier, Paris, France; Centre d'Investigation Clinique (CIC)-1419 Institut National de la Santé Et de la Recherche Médicale (Inserm), Cochin-Necker, Paris, France.
²⁵ Department of Pathology, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
²⁶ Department of Ophthalmology, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris Cité University, Paris, France.
²⁷ Department of Nephrology and Kidney Transplantation, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris Cité University, Paris, France.
²⁸ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé Et de la Recherche Médicale (INSERM) U1163, Imagine Institute, Necker-Enfants Malades Hospital, Paris, France; Paris Cité University, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.
²⁹ Department of Pediatric Pulmonology and Allergology, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
³⁰ Pediatric Nephrology, Maladies REnales Héréditaires de l'Enfant et de l'Adulte (MARHEA) Reference Center, Institut National de la Santé Et de la Recherche Médicale (INSERM) U1163, Imagine Institute, Paris Cité University, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France. Electronic address: olivia.boyer@aphp.fr.

No abstract available

Keywords: COVID-19; SARS-CoV-2; TINUs; pediatric; tubule-interstitial nephritis; uveitis.

MeSH terms

COVID-19* / complications
Child
Humans
Nephritis, Interstitial* / diagnosis
Nephritis, Interstitial* / drug therapy
Post-Acute COVID-19 Syndrome
Uveitis* / diagnosis
Uveitis* / drug therapy
Uveitis* / etiology

Supplementary concepts

Acute Tubulointerstitial Nephritis