Synthesis of 3,4,5-trisubstituted phenols via Rh(III)-catalyzed alkenyl C-H activation assisted by phosphonium cations

Yan Mao; Wenxi Chen; Changchang Li; Lin Miao; Yanfei Lin; Fei Ling; Zhangpei Chen; Jinzhong Yao

doi:10.1039/d3cc00017f

Synthesis of 3,4,5-trisubstituted phenols via Rh(III)-catalyzed alkenyl C-H activation assisted by phosphonium cations

Chem Commun (Camb). 2023 Mar 23;59(25):3775-3778. doi: 10.1039/d3cc00017f.

Authors

Yan Mao^{1

2}, Wenxi Chen^{1

2}, Changchang Li², Lin Miao², Yanfei Lin², Fei Ling¹, Zhangpei Chen³, Jinzhong Yao²

Affiliations

¹ College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. lingfei@zjut.edu.cn.
² College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China. jzyao@zju.edu.cn.
³ Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang 110819, China. chenzhangpei@mail.neu.edu.cn.

PMID: 36912283
DOI: 10.1039/d3cc00017f

Abstract

An efficient method for the construction of various 3,4,5-trisubstituted phenol derivatives has been achieved via the Rh(III)-catalyzed coupling of phosphonium cations with internal alkynes. This protocol shows good substrate compatibility, as an array of structurally and electronically diverse phosphonium compounds react efficiently with up to 87% yield.