Advanced MR Techniques for Preoperative Glioma Characterization: Part 2

J Magn Reson Imaging. 2023 Jun;57(6):1676-1695. doi: 10.1002/jmri.28663. Epub 2023 Mar 13.

Abstract

Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation. This review describes current methods, limits, and applications of advanced MRI for the preoperative assessment of glioma, summarizing the level of clinical validation of different techniques. In this second part, we review magnetic resonance spectroscopy (MRS), chemical exchange saturation transfer (CEST), susceptibility-weighted imaging (SWI), MRI-PET, MR elastography (MRE), and MR-based radiomics applications. The first part of this review addresses dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL), diffusion-weighted MRI, vessel imaging, and magnetic resonance fingerprinting (MRF). EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 2.

Keywords: GliMR 2.0; brain; contrasts; glioma; level of clinical validation; preoperative.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / pathology
  • Brain Neoplasms* / surgery
  • Contrast Media
  • Glioma* / diagnostic imaging
  • Glioma* / pathology
  • Glioma* / surgery
  • Humans
  • Magnetic Resonance Imaging* / methods
  • Magnetic Resonance Spectroscopy / methods
  • Preoperative Period

Substances

  • Contrast Media