Novel regulatory role of non-coding RNAs in ankylosing spondylitis

Front Immunol. 2023 Feb 24:14:1131355. doi: 10.3389/fimmu.2023.1131355. eCollection 2023.

Abstract

Ankylosing spondylitis (AS) is a type of arthritis that primarily affects the spine and involves disorders of the immune and skeletal systems. However, the exact pathogenesis of AS is not fully understood. Non-coding RNAs (ncRNAs), particularly, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and micro RNAs (miRNAs) and their interactions have been shown to influence many biological processes such as inflammatory responses, osteogenic differentiation and apoptosis, pyroptosis, and proliferation. In addition, ncRNAs reflect the disease activity of AS. In this review, we discuss the regulatory roles of ncRNAs in AS cell functions (inflammatory responses, cellular osteogenic differentiation and apoptosis, pyroptosis, and proliferation) and their potential applications in AS diagnosis and treatment. Understanding the role of ncRNAs in the pathogenesis of AS will lay the foundation for exploring potential new therapeutic approaches for AS.

Keywords: ankylosing spondylitis; ceRNA; circRNAs; lncRNAs; miRNAs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • MicroRNAs*
  • Osteogenesis
  • RNA, Long Noncoding*
  • RNA, Untranslated
  • Spondylitis, Ankylosing*

Substances

  • RNA, Untranslated
  • MicroRNAs
  • RNA, Long Noncoding

Grants and funding

This work was supported by grants from the National Nature Fund Program (No. 82104817); the Key Laboratory of Xin’an Medicine of the Ministry of Education, Anhui University of Chinese Medicine (2020xayx08); the 2021 open fund of Anhui Key Laboratory of Applied Basic and Development Research of Modern Internal Medicine of Traditional Chinese Medicine (2021AKLMCM003); Scientific Research Project of Anhui Provincial Health Commission (AHWJ2021b036); Anhui Famous Traditional Chinese Medicine Liu Jian Studio Construction Project (Traditional Chinese Medicine Development Secret (2018) No. 11); Anhui Provincial Laboratory of Applied Basic and Development Research of Modern Internal Medicine of Traditional Chinese Medicine (2016080503B041); Anhui Province Traditional Chinese Medicine Leading Talent Project (Traditional Chinese Medicine Development Secret (2018) No. 23); and the 12th batch of “115” Innovation team of Anhui Province (Anhui Talent Office (2019) No. 1).