Regulation of SUMOylation on RNA metabolism in cancers

Yingting Cao; Caihu Huang; Xian Zhao; Jianxiu Yu

doi:10.3389/fmolb.2023.1137215

Regulation of SUMOylation on RNA metabolism in cancers

Front Mol Biosci. 2023 Feb 24:10:1137215. doi: 10.3389/fmolb.2023.1137215. eCollection 2023.

Authors

Yingting Cao¹, Caihu Huang¹, Xian Zhao¹, Jianxiu Yu¹

Affiliation

¹ Department of Biochemistry and Molecular Cell Biology and Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism including transcription, splicing, tailing, stability and modification, as well as its impact on the biogenesis and function of microRNA (miRNA) in particular. This review also highlights the current knowledge about SUMOylation regulation in RNA metabolism involved in many cellular processes such as cell proliferation and apoptosis, which is closely related to tumorigenesis and cancer progression.

Keywords: RNA editing; cancer; mRNA processing; mRNA transcription; miRNA biogenesis; sumoylation.

Publication types

Review

Grants and funding

This work was supported by China’s National Key R&D Programmes (NKP) (No. 2019YFE0110600) and grants from the National Natural Science Foundation of China (82230100, 32271310, 82273143).