Early Diagnosis of Neurodegenerative Diseases Using CNN-LSTM and Wavelet Transform

Elmira Amooei; Arash Sharifi; Mohammad Manthouri

doi:10.1007/s41666-023-00130-9

Early Diagnosis of Neurodegenerative Diseases Using CNN-LSTM and Wavelet Transform

J Healthc Inform Res. 2023 Feb 13;7(1):104-124. doi: 10.1007/s41666-023-00130-9. eCollection 2023 Mar.

Authors

Elmira Amooei¹, Arash Sharifi¹, Mohammad Manthouri²

Affiliations

¹ Department of Computer Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
² Department of Electrical and Electronic Engineering, Shahed University, Tehran, Iran.

Abstract

Early diagnosis of neurodegenerative diseases has always been a major challenge that physicians and medical practitioners face. Therefore, using any method or device that helps with prognostics is of great importance. In recent years, deep neural networks have become popular in medical fields, and the reason is that these networks can help diagnose diseases quickly and precisely. In this research, two novel models based on a CNN-LSTM network are introduced. The main goal is to classify three neurodegenerative diseases, including ALS, Parkinson's disease, and Huntington's disease, from one another and from healthy control patients using the gait signals, which are transformed into spectrogram images. In the first model, the spectrogram images derived from the gait signals are fed into a CNN-LSTM network directly. This model achieved 99.42% accuracy. In the second model, the same input data was used to be classified using a CNN-LSTM network, which uses wavelet transform as a feature extractor before the LSTM unit. During the experiments with the second model, the detail sub-bands were eliminated one by one, and the classification results were compared. Comparing these two models has shown that using the wavelet transform and, in particular, the approximation sub-bands can result in a lighter and faster prognosis with nearly 103 times fewer training parameters overall. The classification result using only approximation sub-bands was 95.37%, using three sub-bands was 94.04%, and including all sub-bands was 94.53%, which is remarkable.

Keywords: CNN-LSTM; Deep neural networks; Neurodegenerative diseases; Spectrogram; Wavelet transform.

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