Maternal serum iron status, hepcidin and interleukin-6 levels in women with preeclampsia

Yasir I B Ahmed; Hind S Yagoub; Mohamed A Hassan; I Adam; Hamdan Z Hamdan

doi:10.3389/fphys.2023.1049994

Maternal serum iron status, hepcidin and interleukin-6 levels in women with preeclampsia

Front Physiol. 2023 Feb 24:14:1049994. doi: 10.3389/fphys.2023.1049994. eCollection 2023.

Authors

Yasir I B Ahmed¹, Hind S Yagoub^{1

2}, Mohamed A Hassan³, I Adam⁴, Hamdan Z Hamdan^{5

6}

Affiliations

¹ Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan.
² Faculty of Medical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia.
³ Africa City of Technology, Khartoum, Sudan.
⁴ Department of Obstetrics and Gynaecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
⁵ Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia.
⁶ Faculty of Medicine, Al-Neelain University, Khartoum, Sudan.

Abstract

Introduction: Preeclampsia can lead to a number of adverse maternal and perinatal effects. The association between iron status [serum iron, ferritin and total iron-binding capacity (TIBC)], unsaturated iron-binding capacity, hepcidin, interleukin-6 (IL-6) levels and preeclampsia is not fully understood. Objective: To assess the levels of iron status, hepcidin and interleukin-6 in women with preeclampsia compared with healthy pregnant women. Method: A case-control study (60 women were recruited in each group) was conducted at Saad Abuelela Maternity Hospital in Khartoum, Sudan. Sociodemographic and clinical data were gathered through a questionnaire. The levels of iron status, hepcidin and IL-6 were measured using applicable methods. Results: There was no significant difference in the median [interquartile range (IQR)] of age, parity or body mass index between the two groups. Moreover, the median (IQR) of the iron status, hepcidin and interleukin-6 did not differ between women with preeclampsia and healthy controls. There were no significant correlations between haemoglobin, hepcidin and IL-6. There were also no significant correlations between serum iron, serum ferritin, hepcidin and IL-6. However, there was a significant positive correlation between hepcidin and IL-6 (r = 0.393, p = 0.002). Conclusion: In this study, women with preeclampsia had levels of iron status, hepcidin and IL-6 similar to those observed in healthy pregnant women. There was no significant correlation between iron status, hepcidin and IL-6.

Keywords: IL-6; hepcidin; iron homeostasis; preeclampsia; sub-Sahara Africa.