Insights into bone morphogenetic proteins in cardiovascular diseases

Di Ye; Yinghui Liu; Heng Pan; Yongqi Feng; Xiyi Lu; Liren Gan; Jun Wan; Jing Ye

doi:10.3389/fphar.2023.1125642

Insights into bone morphogenetic proteins in cardiovascular diseases

Front Pharmacol. 2023 Feb 23:14:1125642. doi: 10.3389/fphar.2023.1125642. eCollection 2023.

Authors

Di Ye^{1

2

3}, Yinghui Liu⁴, Heng Pan^{1

2

3}, Yongqi Feng^{1

2

3}, Xiyi Lu^{1

2

3}, Liren Gan^{1

2

3}, Jun Wan^{1

2

3}, Jing Ye^{1

2

3}

Affiliations

¹ Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
² Cardiovascular Research Institute, Wuhan University, Wuhan, China.
³ Hubei Key Laboratory of Cardiology, Wuhan, China.
⁴ Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.

Abstract

Bone morphogenetic proteins (BMPs) are secretory proteins belonging to the transforming growth factor-β (TGF-β) superfamily. These proteins play important roles in embryogenesis, bone morphogenesis, blood vessel remodeling and the development of various organs. In recent years, as research has progressed, BMPs have been found to be closely related to cardiovascular diseases, especially atherosclerosis, vascular calcification, cardiac remodeling, pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT). In this review, we summarized the potential roles and related mechanisms of the BMP family in the cardiovascular system and focused on atherosclerosis and PAH.

Keywords: BMP; atherosclerosis; cardiac remodeling; diabetic cardiomyopathy; hereditary hemorrhagic telangiectasia; hypertension; pulmonary arterial hypertension; vascular calcification.

Publication types

Review

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (82070436).