The potential role of nanomedicine in the treatment of breast cancer to overcome the obstacles of current therapies

Fan Yang; Qingjie He; Xiangpeng Dai; Xiaoling Zhang; Dong Song

doi:10.3389/fphar.2023.1143102

The potential role of nanomedicine in the treatment of breast cancer to overcome the obstacles of current therapies

Front Pharmacol. 2023 Feb 22:14:1143102. doi: 10.3389/fphar.2023.1143102. eCollection 2023.

Authors

Fan Yang^{1

2

3}, Qingjie He^{1

2

3}, Xiangpeng Dai^{2

3}, Xiaoling Zhang^{2

3}, Dong Song¹

Affiliations

¹ Breast Surgery Department of General Surgery, The First Hospital of Jilin University, Changchun, China.
² Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China.
³ National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China.

Abstract

Breast cancer (BC) is the most frequently diagnosed malignant tumor among women in the world. BC is the heterogeneous tumor with different subtypes including luminal A-like, luminal B-like (HER2-/HER2+), HER2 enriched, and triple-negative BC. The therapeutic strategies including surgery, chemotherapy, radiotherapy, targeted therapy, and endocrine therapy are well developed and commonly used in the treatment of BC. However, some adverse effects of these conventional treatments limited their wide application in clinical. Therefore, it is necessary to develop more safe and more efficient individualized treatment strategies of the BC. Nanomedicine, as the most promising strategy for controlled and targeted drug delivery, is widely used in multiple aspects of cancer therapy. Importantly, accumulative evidences show that nanomedicine has achieved good outcomes in the treatment of BC and a huge amount of BC patients benefited from the nanomedicine related treatments. In this review, we summarized and discussed the major problems occurred during the administration of conventional treatment strategies for BC and the potential roles of nanomedicine in promoting the treatment efficacy of BC by overcoming obstacles of current treatment of BC.

Keywords: breast cancer; combined therapy; drug delivery; drug resistance; nanomedicine.

Publication types

Review

Grants and funding

This work was partly supported by the National Natural Science Foundation of China (No.: 81972558, No.: 81802815), the Natural Science Foundation of Jilin Province (No: 20210401057YY, No: 20200201367JC, No.: 20210204165YY, No.: 20200201473JC), the “Startup funding of First Hospital, JLU.”