Data on lung and intestinal microbiome after air pollution exposure in ageing rats

Vincent Laiman; Yu-Chun Lo; Hsin-Chang Chen; Tzu-Hsuen Yuan; Ta-Chih Hsiao; Jen-Kun Chen; Ching-Wen Chang; Ting-Chun Lin; Ssu-Ju Li; You-Yin Chen; Didik Setyo Heriyanto; Kian Fan Chung; Kai-Jen Chuang; Kin-Fai Ho; Jer-Hwa Chang; Hsiao-Chi Chuang

doi:10.1016/j.dib.2023.109004

Data on lung and intestinal microbiome after air pollution exposure in ageing rats

Data Brief. 2023 Feb 23:47:109004. doi: 10.1016/j.dib.2023.109004. eCollection 2023 Apr.

Authors

Vincent Laiman^{1

2}, Yu-Chun Lo³, Hsin-Chang Chen⁴, Tzu-Hsuen Yuan⁵, Ta-Chih Hsiao⁶, Jen-Kun Chen⁷, Ching-Wen Chang⁸, Ting-Chun Lin⁹, Ssu-Ju Li⁹, You-Yin Chen^{3

8

9}, Didik Setyo Heriyanto², Kian Fan Chung¹⁰, Kai-Jen Chuang^{11

12}, Kin-Fai Ho¹³, Jer-Hwa Chang^{14

15}, Hsiao-Chi Chuang^{10

14

16

17

18}

Affiliations

¹ International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
² Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia.
³ Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
⁴ Department of Chemistry, College of Science, Tunghai University, Taichung, Taiwan.
⁵ Department of Health and Welfare, College of City Management, University of Taipei, Taipei, Taiwan.
⁶ Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan.
⁷ Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes, Miaoli, Taiwan.
⁸ Industrial Ph.D. Program of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
⁹ Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
¹⁰ National Heart and Lung Institute, Imperial College London, London, UK.
¹¹ School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
¹² Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
¹³ School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong.
¹⁴ School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wuxing Street, Taipei 11031, Taiwan.
¹⁵ Division of Pulmonary Medicine, Departments of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁶ Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
¹⁷ Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁸ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Abstract

Air pollution has been linked to respiratory diseases, and urban air pollution can be attributed to a number of emission sources. The emitted particles and gases are the primary components of air pollution that enter the lungs during respiration. Particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM_2.5) can deposit deep into the respiratory tract via inhalation and has been proposed as a causative agent for adverse respiratory health. In addition, the lung contains a diverse microbial community (microbiome) that maintains normal homeostasis and is significantly altered in a variety of pulmonary disorders. Air pollution, specifically PM_2.5, has previously been shown to significantly alter the composition of the lower airway microbiome, which has been linked to decreased lung function in chronic obstructive pulmonary disease (COPD) patients. Surprisingly, the intestinal microbiome has also been implicated in the modulation of pulmonary inflammatory diseases. Therefore, dysbiosis of the lung and intestinal microbiomes pose significant negative effects on human health. This dataset describes the microbial community profiles of the lungs and intestines of ageing rats exposed to ambient unconcentrated traffic-related air pollution for three months. The whole-body exposure system was equipped with and without high efficiency particulate air (HEPA) filtration (gaseous vs. PM_2.5 pollution). The data can provide valuable information on lung and intestinal microbiome changes, including that which was only found after traffic-related air pollution exposure.

Keywords: Air pollution; Intestinal microbiome; Lung microbiome; PM2.5.