Sleep, Sirtuin 1 and Alzheimer's disease: A review

Mehrane Mehramiz; Tenielle Porter; Simon M Laws; Stephanie R Rainey-Smith

doi:10.1016/j.nbas.2022.100050

Sleep, Sirtuin 1 and Alzheimer's disease: A review

Aging Brain. 2022 Sep 9:2:100050. doi: 10.1016/j.nbas.2022.100050. eCollection 2022.

Authors

Mehrane Mehramiz^{1

2}, Tenielle Porter^{1

2

3}, Simon M Laws^{1

2

3}, Stephanie R Rainey-Smith^{4

5

6

7

8}

Affiliations

¹ Centre for Precision Health, Edith Cowan University, Joondalup, WA, Australia.
² Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
³ School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, WA, Australia.
⁴ Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, WA, Australia.
⁵ Lifestyle Approaches Towards Cognitive Health Research Group, Murdoch University, Murdoch, WA, Australia.
⁶ Australian Alzheimer's Research Foundation (Ralph and Patricia Sarich Neuroscience Research Institute), Nedlands, WA, Australia.
⁷ Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, WA, Australia.
⁸ School of Psychological Science, University of Western Australia, Crawley, WA, Australia.

Abstract

Sleep plays a major role in brain health, and cognition. Disrupted sleep is a well-described symptom of Alzheimer's disease (AD). However, accumulating evidence suggests suboptimal sleep also increases AD risk. The deacetylase Sirtuin 1 (Sirt 1), encoded by the SIRT1 gene, impacts sleep via its relationship to wake-sleep neurotransmitters and somnogens. Evidence from animal and human studies supports a significant and complex relationship between sleep, Sirt 1/ SIRT1 and AD. Numerous hypotheses attempt to explain the critical impact of Sirt 1/ SIRT1 on wake- and sleep- promoting neurons, their related mechanisms and neurotransmitters. However, there is a paucity of studies assessing the interaction between sleep and Sirt 1/ SIRT1, as a principal component of sleep regulation, on AD pathology. In this review, we explore the potential association between Sirt 1/ SIRT1, sleep, and AD aetiology. Given sleep is a likely modifiable risk factor for AD, and recent studies suggest Sirt 1/ SIRT1 activation can be modulated by lifestyle or dietary approaches, further research in this area is required to explore its potential as a target for AD prevention and treatment.

Keywords: Alzheimer’s disease; Aβ-amyloid; Circadian clock; Dementia; Homeostasis; Neurotransmitter; SIRT1; Sirtuin 1; Sleep; Tau.

Publication types

Review