Adverse health effects of emerging contaminants on inflammatory bowel disease

Xuejie Chen; Sidan Wang; Xueyi Mao; Xin Xiang; Shuyu Ye; Jie Chen; Angran Zhu; Yifei Meng; Xiya Yang; Shuyu Peng; Minzi Deng; Xiaoyan Wang

doi:10.3389/fpubh.2023.1140786

Adverse health effects of emerging contaminants on inflammatory bowel disease

Front Public Health. 2023 Feb 24:11:1140786. doi: 10.3389/fpubh.2023.1140786. eCollection 2023.

Authors

Xuejie Chen^{1

2}, Sidan Wang^{1

2}, Xueyi Mao³, Xin Xiang³, Shuyu Ye^{1

2}, Jie Chen^{1

4}, Angran Zhu³, Yifei Meng³, Xiya Yang³, Shuyu Peng³, Minzi Deng^{1

2}, Xiaoyan Wang^{1

2}

Affiliations

¹ Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
² Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha, Hunan, China.
³ Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
⁴ Centre for Global Health, Zhejiang University, Hangzhou, China.

Abstract

Inflammatory bowel disease (IBD) is becoming increasingly prevalent with the improvement of people's living standards in recent years, especially in urban areas. The emerging environmental contaminant is a newly-proposed concept in the progress of industrialization and modernization, referring to synthetic chemicals that were not noticed or researched before, which may lead to many chronic diseases, including IBD. The emerging contaminants mainly include microplastics, endocrine-disrupting chemicals, chemical herbicides, heavy metals, and persisting organic pollutants. In this review, we summarize the adverse health effect of these emerging contaminants on humans and their relationships with IBD. Therefore, we can better understand the impact of these new emerging contaminants on IBD, minimize their exposures, and lower the future incidence of IBD.

Keywords: adverse health effects (AHEs); emerging contaminant (EC); exposome; gut dysbiosis; inflammatory bowel disease.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Inflammatory Bowel Diseases* / etiology
Metals, Heavy*
Plastics

Substances

Plastics
Metals, Heavy

Grants and funding

This work was supported by the National Natural Science Foundation of China (81970494) and Key Project of Research and Development Plan of Hunan Province (2019SK2041).