Start of life controlled by poly(A) tail-mediated remodeling

Chunxia Zhang; Yi Zhang

doi:10.1016/j.tig.2023.03.001

Start of life controlled by poly(A) tail-mediated remodeling

Trends Genet. 2023 May;39(5):340-341. doi: 10.1016/j.tig.2023.03.001. Epub 2023 Mar 10.

Authors

Chunxia Zhang¹, Yi Zhang²

Affiliations

¹ State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. Electronic address: cxzhang@genetics.ac.cn.
² Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, MA, USA; Harvard Stem Cell Institute, 200 Longwood Avenue, Boston, MA 02115, USA. Electronic address: yzhang@genetics.med.harvard.edu.

PMID: 36907722
DOI: 10.1016/j.tig.2023.03.001

Abstract

Understanding a remarkable event at the start of life, the oocyte-to-embryo transition (OET), has remained elusive, especially in humans. Using newly developed techniques, Liu et al. showed that human maternal mRNAs undergo global poly(A) tail-mediated remodeling during OET, identified the enzymes involved, and demonstrated the essentiality of remodeling for embryo cleavage.

Keywords: PAIso-seq; human; oocyte-to-embryo transition (OET); poly(A) tail; post-transcriptional regulation.

MeSH terms

Humans
Oocytes*
RNA, Messenger
RNA, Messenger, Stored*

Substances

RNA, Messenger
RNA, Messenger, Stored