Clinical Complications and Their Management

Rayan Bou-Fakhredin; Irene Motta; Maria Domenica Cappellini; Ali T Taher

doi:10.1016/j.hoc.2022.12.007

Clinical Complications and Their Management

Hematol Oncol Clin North Am. 2023 Apr;37(2):365-378. doi: 10.1016/j.hoc.2022.12.007.

Authors

Rayan Bou-Fakhredin¹, Irene Motta², Maria Domenica Cappellini², Ali T Taher³

Affiliations

¹ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
² Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; UOC General Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
³ Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address: ataher@aub.edu.lb.

PMID: 36907609
DOI: 10.1016/j.hoc.2022.12.007

Abstract

The diversity of disease-related complications among patients with β-thalassemia is complicated by the wide spectrum of genotypes and clinical risk factors. The authors herein present the different complications seen in patients with β-thalassemia, the pathophysiology underlying these complications and their management.

Keywords: Complications; Endocrine; Heart; Ineffective erythropoiesis; Iron overload; Liver; Management; β-Thalassemia.

Publication types

Review

MeSH terms

Erythropoiesis
Humans
Iron Overload*
Risk Factors
beta-Thalassemia* / genetics