The current state of the art in gellan-based printing inks in tissue engineering

Abstract

With the advancement of enhanced fabrication technologies, specifically 3D printing, it is now possible to build artificial tissue for personalized healing. However, inks developed from polymers often fail to meet expectations in terms of mechanical strength, scaffold integrity, and the stimulation of tissue formation. Developing new printable formulations as well as adapting existing printing methods is an essential aspect of contemporary biofabrication research. In order to push the boundaries of the printability window, various strategies have been developed employing gellan gum. This has resulted in major breakthroughs in the development of 3D hydrogels scaffolds that exhibit significant resemblance to genuine tissues and enables the fabrication of more complex systems. In light of the many uses of gellan gum, the purpose of this paper is to provide a synopsis of the printable ink designs drawing attention to the various compositions and fabrication approaches that may be used for tuning the properties of 3D printed hydrogels for tissue engineering applications. The purpose of this article is to outline the development of gellan-based 3D printing inks and to encourage research by highlighting the possible applications of gellan gum.

Keywords: 3D bioprinting; Bioink; Gellan gum; Tissue engineering.