Sodium alginate-based drug delivery for diabetes management: A review

Mohammad Arshad Javed Shaikh; Gaurav Gupta; Obaid Afzal; Madan Mohan Gupta; Ahsas Goyal; Abdulmalik Saleh Alfawaz Altamimi; Sami I Alzarea; Waleed Hassan Almalki; Imran Kazmi; Poonam Negi; Sachin Kumar Singh; Kamal Dua

doi:10.1016/j.ijbiomac.2023.123986

Sodium alginate-based drug delivery for diabetes management: A review

Int J Biol Macromol. 2023 May 1:236:123986. doi: 10.1016/j.ijbiomac.2023.123986. Epub 2023 Mar 10.

Affiliations

¹ School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India; Department of Pharmacy, TPCT's College of Engineering, Osmanabad, Maharashtra, India.
² School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India. Electronic address: gauravpharma25@gmail.com.
³ Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
⁴ School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustus, Trinidad and Tobago, WI.
⁵ Institute of Pharmaceutical Research, GLA University, U.P., India.
⁶ Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
⁷ Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
⁸ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
⁹ School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, India.
¹⁰ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
¹¹ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia.

PMID: 36906199
DOI: 10.1016/j.ijbiomac.2023.123986

Abstract

Diabetes mellitus (DM) is among the biggest global health problems of the 21st century, which is characterised by insufficient insulin secretion and results in the augmentation of blood sugar levels. The current foundation of hyperglycemia therapy is oral antihyperglycemic medications like biguanides, sulphonylureas, α-glucosidase inhibitors, peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists, sodium-glucose co-transporter 2 (SGLT-2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors and others. Many naturally occurring substances have shown promise in treating hyperglycemia. Inadequate prologitivity of action, restricted bioavailability, site specificity, and dose-related side effects are some problems with currently available anti-diabetic medications. Sodium alginate has shown promise as a drug delivery mechanism, potentially solving issues with current therapies for several substances. This review summarizes the research on the efficacy of drug delivery systems based on alginate for transporting oral hypoglycemic medicines, phytochemicals, and insulin for treating hyperglycemia.

Keywords: Diabetes; Drug delivery; Hyperglycemia; Insulin; Polysaccharides; Sodium alginate.

Publication types

Review

MeSH terms

Diabetes Mellitus, Type 2* / drug therapy
Dipeptidyl-Peptidase IV Inhibitors*
Humans
Hyperglycemia* / chemically induced
Hyperglycemia* / drug therapy
Hypoglycemic Agents / pharmacology
Insulin / therapeutic use
Sodium-Glucose Transporter 2 Inhibitors* / therapeutic use

Substances

Hypoglycemic Agents
Dipeptidyl-Peptidase IV Inhibitors
Insulin
Sodium-Glucose Transporter 2 Inhibitors