Manganese oxide-modified bismuth oxychloride piezoelectric nanoplatform with multiple enzyme-like activities for cancer sonodynamic therapy

Yunchao Zhao; Tian Huang; Shaobo Wang; Shuncheng Yao; Quanhong Hu; Xingyi Wan; Ning Guo; Yang Zhang; Linlin Li

doi:10.1016/j.jcis.2023.03.008

Manganese oxide-modified bismuth oxychloride piezoelectric nanoplatform with multiple enzyme-like activities for cancer sonodynamic therapy

J Colloid Interface Sci. 2023 Jun 15:640:839-850. doi: 10.1016/j.jcis.2023.03.008. Epub 2023 Mar 7.

Authors

Yunchao Zhao¹, Tian Huang¹, Shaobo Wang¹, Shuncheng Yao², Quanhong Hu¹, Xingyi Wan², Ning Guo³, Yang Zhang⁴, Linlin Li⁵

Affiliations

¹ Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100140, PR China; Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, PR China.
² Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100140, PR China; Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, PR China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, PR China.
³ Key Laboratory of Semiconductor Material Sciences, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, 100083, PR China; College of Materials Science and Optoelectronic Devices, University of Chinese Academy of Sciences, 100049, PR China.
⁴ Key Laboratory of Semiconductor Material Sciences, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, 100083, PR China; College of Materials Science and Optoelectronic Devices, University of Chinese Academy of Sciences, 100049, PR China. Electronic address: zhang_yang@semi.ac.cn.
⁵ Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100140, PR China; Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, PR China; School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: lilinlin@binn.cas.cn.

PMID: 36905893
DOI: 10.1016/j.jcis.2023.03.008

Abstract

Sonodynamic therapy (SDT) is considered as a new-rising strategy for cancer therapeutics, but the inefficient production of reactive oxygen species (ROS) by current sonosensitizers seriously hinders its further applications. Herein, a piezoelectric nanoplatform is fabricated for enhancing SDT against cancer, in which manganese oxide (MnO_x) with multiple enzyme-like activities is loaded on the surface of piezoelectric bismuth oxychloride nanosheets (BiOCl NSs) to form a heterojunction. When exposed to ultrasound (US) irradiation, piezotronic effect can remarkably promote the separation and transport of US-induced free charges, and further enhance ROS generation in SDT. Meanwhile, the nanoplatform shows multiple enzyme-like activities from MnO_x, which can not only downregulate the intracellular glutathione (GSH) level, but also disintegrate endogenous hydrogen peroxide (H₂O₂) to generate oxygen (O₂) and hydroxyl radicals (•OH). As a result, the anticancer nanoplatform substantially boosts ROS generation and reverses tumor hypoxia. Ultimately, it reveals remarkable biocompatibility and tumor suppression in a murine model of 4 T1 breast cancer under US irradiation. This work provides a feasible pathway for improving SDT using piezoelectric platforms.

Keywords: Bismuth oxychloride; Enzyme-like activity; Manganese oxide; Piezotronic effect; Sonodynamic therapy.

MeSH terms

Animals
Cell Line, Tumor
Humans
Hydrogen Peroxide*
Mice
Neoplasms* / therapy
Oxygen / metabolism
Reactive Oxygen Species / metabolism

Substances

Reactive Oxygen Species
manganese oxide
bismuth oxychloride
Hydrogen Peroxide
Oxygen