Updated Progress of the Copper-Catalyzed Borylative Functionalization of Unsaturated Molecules

Bingru Li; Huayu Liang; Arumugam Vignesh; Xiaoyu Zhou; Yan Liu; Zhuofeng Ke

doi:10.3390/molecules28052252

Updated Progress of the Copper-Catalyzed Borylative Functionalization of Unsaturated Molecules

Molecules. 2023 Feb 28;28(5):2252. doi: 10.3390/molecules28052252.

Authors

Bingru Li¹, Huayu Liang¹, Arumugam Vignesh^{1

2}, Xiaoyu Zhou¹, Yan Liu^{2

3}, Zhuofeng Ke¹

Affiliations

¹ School of Materials Science and Engineering, PCFM Lab, Sun Yat-sen University, Guangzhou 510275, China.
² School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
³ Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510275, China.

Abstract

Borylation has become a powerful method to synthesize organoboranes as versatile building blocks in organic synthesis, medicinal chemistry, and materials science. Copper-promoted borylation reactions are extremely attractive due to the low cost and non-toxicity of the copper catalyst, mild reaction conditions, good functional group tolerance, and convenience in chiral induction. In this review, we mainly updated recent advances (from 2020 to 2022) in the synthetic transformations in C=C/C≡C multiple bonds, and C=E multiple bonds mediated by copper boryl systems.

Keywords: borylation; carboborylation; copper; hydroboration; multiple bonds.

Publication types

Review

Abstract

Publication types

Grants and funding