The Role of m6A Modifications in B-Cell Development and B-Cell-Related Diseases

Shuqi Wang; Huanxiang Li; Zhengxing Lian; Shoulong Deng

doi:10.3390/ijms24054721

The Role of m⁶A Modifications in B-Cell Development and B-Cell-Related Diseases

Int J Mol Sci. 2023 Mar 1;24(5):4721. doi: 10.3390/ijms24054721.

Authors

Shuqi Wang¹, Huanxiang Li¹, Zhengxing Lian¹, Shoulong Deng²

Affiliations

¹ Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
² NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.

Abstract

B cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. m⁶A modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can affect RNA splicing, translation, stability, etc. This review focuses on the B-cell maturation process as well as the role of three m⁶A modification-related regulators-writer, eraser, and reader-in B-cell development and B-cell-related diseases. The identification of genes and modifiers that contribute to immune deficiency may shed light on regulatory requirements for normal B-cell development and the underlying mechanism of some common diseases.

Keywords: B cell; B-cell-related diseases; immunodeficiency; m6A.

Publication types

Review

MeSH terms

Cell Differentiation
RNA Splicing*
RNA, Messenger / genetics

Substances

RNA, Messenger

Grants and funding

This work was supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CAMS-I2M, 2021-I2M-1-072), the National Key Research and Development Project of China (2021YFF1000704), and the Natural Science Foundation of China (32072722).