Since early 2020, the rapid expansion of COVID-19 has raised concerns about vaccine safety and the government's handling of it. Particularly notable and concerning has been a growing number of people who oppose vaccines, as this opposition poses a threat to public health. Those for and against vaccination have become polarized along a political divide. Within this context, this study focuses on the role of political trust, exploring whether political ideology is associated with the perception that the government can ensure the safety of vaccines and whether there is a moderator that can alleviate the concerns of those who oppose the government's handling of vaccine safety on ideological grounds. This study relies on the 2021 U.S. General Social Survey (GSS) and employs an ordered probit method because the dependent variable is an ordered category. The ordered probit model includes a weight provided by the U.S. GSS to account for the population. The sample size was 473 because of the inclusion of all the variables relevant to this study. The results obtained are as follows: First, conservatives associate negatively with support for the government's handling of vaccine safety. Second, more importantly, conservatives exhibit a higher trust level toward the government to ensure vaccine safety if their level of political trust increases. The results point to important implications. Political ideology matters in how individuals view the government's handling of vaccine safety. Political trust plays a key role in helping individuals alter their views toward the government's handling of vaccine safety. This points to a need for the government to take political trust seriously and work hard to improve the public's trust in the government.
Keywords: government ensuring vaccine safety; political ideology; political trust.