Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia

Rosa Calvello; Chiara Porro; Dario Domenico Lofrumento; Melania Ruggiero; Maria Antonietta Panaro; Antonia Cianciulli

doi:10.3390/cells12050681

Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia

Cells. 2023 Feb 21;12(5):681. doi: 10.3390/cells12050681.

Authors

Rosa Calvello¹, Chiara Porro², Dario Domenico Lofrumento³, Melania Ruggiero¹, Maria Antonietta Panaro¹, Antonia Cianciulli¹

Affiliations

¹ Department of Biosciences, Biotechnologies and Environment, University of Bari, I-70125 Bari, Italy.
² Department of Clinical and Experimental Medicine, University of Foggia, I-71100 Foggia, Italy.
³ Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, I-73100 Lecce, Italy.

Abstract

Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's diseases (PD). In the present study, we report that the treatment of activated microglia with resveratrol after prolonged exposure to lipopolysaccharide is not only able to modulate pro-inflammatory responses, but it also up-regulates the expression of decoy receptors, IL-1R2 and ACKR2 (atypical chemokine receptors), also known as negative regulatory receptors, which are able to reduce the functional responses promoting the resolution of inflammation. This result might constitute a hitherto unknown anti-inflammatory mechanism exerted by resveratrol on activated microglia.

Keywords: cytokines; decoy receptors; lipopolysaccharide; microglia; resveratrol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / metabolism
Cytokines / metabolism
Lipopolysaccharides* / metabolism
Microglia* / metabolism
Resveratrol / metabolism

Substances

Resveratrol
Lipopolysaccharides
Cytokines
Anti-Inflammatory Agents

Grants and funding

Publication realized with the co-financing of the European union—Next Generation EU: NRRP Initiative, Mission 4, Component 2, Investment 1.3—Partnerships extended to universities, research centers, companies and research D.D. MUR n. 341 del 15.03.2022, Next Generation EU (PE00000006 “MNESYS”).