Noncontact Charge Shielding Knife for Liquid Microfluidics

J Am Chem Soc. 2023 Mar 22;145(11):6420-6427. doi: 10.1021/jacs.2c13674. Epub 2023 Mar 10.

Abstract

Multibehavioral droplet manipulation in a precise and programmed manner is crucial for stoichiometry, biological virus detection, and intelligent lab-on-a-chip. Apart from fundamental navigation, merging, splitting, and dispensing of the droplets are required for being combined in a microfluidic chip as well. Yet, existing active manipulations including strategies from light to magnetism are arduous to use to split liquids on superwetting surfaces without mass loss and contamination, because of the high cohesion and Coanda effect. Here, we demonstrate a charge shielding mechanism (CSM) for platforms to integrate with a series of functions. In response to attachment of shielding layers from the bottom, the instantaneous and repeatable change of local potential on our platform achieves the desired loss-free manipulation of droplets, with a wide-ranging surface tension from 25.7 mN m-1 to 87.6 mN m-1, functioning as a noncontact air knife to cleave, guide, rotate, and collect reactive monomers on demand. With further refinement of the surface circuit, the droplets, just as the electron, can be programmed to be transported directionally at extremely high speeds of 100 mm s-1. This new generation of microfluidics is expected to be applied in the field of bioanalysis, chemical synthesis, and diagnostic kit.