A New Monoterpene Alkaloid from Incarvillea sinensis with Migration Inhibitory Activity on Cancer Cell

Chem Biodivers. 2023 Apr;20(4):e202201203. doi: 10.1002/cbdv.202201203. Epub 2023 Mar 24.

Abstract

A novel monoterpene alkaloid, named incarvine G, was isolated from the Incarvillea sinensis Lam. Its chemical structure was elucidated using comprehensive spectroscopic methods. Incarvine G is an ester compound comprised of a monoterpene alkaloid and glucose. This compound showed evident inhibition on cell migration, invasion, and cytoskeleton formation of human MDA-MB-231 with low cytotoxicity.

Keywords: Incarvillea sinensis; cytoskeleton; incarvine G; invasion; migration; monoterpene alkaloid.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / pharmacology
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Bignoniaceae* / chemistry
  • Cell Migration Inhibition / drug effects
  • Humans
  • Molecular Structure
  • Monoterpenes* / chemistry
  • Monoterpenes* / pharmacology

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Monoterpenes