Chronic Oral Amiodarone as a Cause of Acute Liver Failure

Evelyn Calderon-Martinez; Samanta Landazuri-Navas; Gizem Kaya; John Cinicola

doi:10.14740/jmc4044

Chronic Oral Amiodarone as a Cause of Acute Liver Failure

J Med Cases. 2023 Feb;14(2):59-63. doi: 10.14740/jmc4044. Epub 2023 Feb 25.

Authors

Evelyn Calderon-Martinez¹, Samanta Landazuri-Navas², Gizem Kaya¹, John Cinicola¹

Affiliations

¹ Department of Internal Medicine Residency, UPMCH Harrisburg Hospital, Harrisburg, PA, USA.
² Department of Internal Medicine, University of the Americas, Quito, Ecuador.

Abstract

Acute liver failure (ALF) is a rare condition that can have a variable clinical course and potentially fatal outcomes. Medication toxicity is a known etiology, however liver failure induced by amiodarone is rare and has been reported mostly in the setting of intravenous (IV) infusion. We present an 84-year-old patient who developed ALF after chronic use of oral amiodarone. The patient received supportive care and her symptoms improved.

Keywords: Acute liver failure; Adverse reaction; Amiodarone; Hepatotoxicity.

Publication types

Case Reports