Two sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike

Massimo Ciccozzi; Stefano Pascarella

doi:10.2217/fvl-2022-0181

Two sides of the same coin: the N-terminal and the receptor binding domains of SARS-CoV-2 Spike

Future Virol. 2023 Feb:10.2217/fvl-2022-0181. doi: 10.2217/fvl-2022-0181. Epub 2023 Mar 6.

Authors

Massimo Ciccozzi¹, Stefano Pascarella²

Affiliations

¹ Medical Statistic & Molecular Epidemiology Unit, University of Biomedical Campus, Rome, Italy.
² Department of Biochemical Sciences 'A Rossi Fanelli', Sapienza Università di Roma, Rome, 00185, Italy.

Abstract

The SARS-CoV-2 Spike receptor binding domain and N-terminal domain interact with each other in an intricate mechanism. Mutations modulate the interplay between the Spike and host molecules. This editorial comments on the intricacies of SARS-CoV-2 Spike interactions.

Keywords: AXL; IntAct; N-terminal domain; SARS-CoV-2; Spike; allosteric interaction; electrostatic potential; indels; receptor binding domain; sialoside.

Publication types

Editorial