Combined targeting of CCL7 and Flt3L to promote the expansion and infiltration of cDC1s in tumors enhances T-cell activation and anti-PD-1 therapy effectiveness in NSCLC

Affiliations

• ¹ Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute and Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, 430071, China.
• ² College of Life Sciences, Wuhan University, Wuhan, 430072, China.
• ³ CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
• ⁴ TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430071, China.
• ⁵ Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
• ⁶ Cancer Center, Renmin Hospital of Wuhan University, Medical Research Institute and Frontier Science Center of Immunology and Metabolism, Wuhan University, Wuhan, 430071, China. lindandan@whu.edu.cn.