Postnatal corticosteroid treatment as a risk factor for false positivity in severe combined immunodeficiency newborn screening

J Microbiol Immunol Infect. 2023 Aug;56(4):871-874. doi: 10.1016/j.jmii.2023.02.001. Epub 2023 Feb 28.

Abstract

From 2011, 37 children were referred to a hospital due to low levels of T cell receptor excision circles (TRECs) from newborn screening. Among them, three children were immunologically characterized and followed up to show that postnatal corticosteroid usage may be among the causes of false positivity in TRECs screening.

Keywords: Corticosteroid; False positive; Newborn screening; SCID; Severe combined immunodeficiency.

MeSH terms

  • Child
  • DNA
  • Humans
  • Infant, Newborn
  • Neonatal Screening*
  • Receptors, Antigen, T-Cell
  • Risk Factors
  • Severe Combined Immunodeficiency* / diagnosis

Substances

  • DNA
  • Receptors, Antigen, T-Cell