Getaway car: Fungal HscA steers human phagosomal p11 into an escape route

Emma Camacho; Carolina Coelho

doi:10.1016/j.chom.2023.02.006

Getaway car: Fungal HscA steers human phagosomal p11 into an escape route

Cell Host Microbe. 2023 Mar 8;31(3):324-327. doi: 10.1016/j.chom.2023.02.006.

Authors

Emma Camacho¹, Carolina Coelho²

Affiliations

¹ W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
² MRC Centre for Medical Mycology at University of Exeter, Exeter, EX4 4QD Devon, UK. Electronic address: c.coelho@exeter.ac.uk.

PMID: 36893729
DOI: 10.1016/j.chom.2023.02.006

Abstract

In this issue of Cell Host & Microbe, Jia and colleagues discover how the human p11 (s100A10)-Anxa2 heterodimer drives sorting of microbial phagosomes into recycling versus degradative pathways. In a remarkable evolutionary arms race, the Aspergillus fumigatus protein HscA latches to p11 to steer its phagosome away from fungal killing.

MeSH terms

Aspergillus fumigatus
Fungal Proteins / metabolism
Humans
Phagosomes* / metabolism
Protein Transport

Substances

Fungal Proteins

Grants and funding

MR/V033417/1/MRC_/Medical Research Council/United Kingdom