Co-infection of tick-borne bacterial pathogens in ticks in Inner Mongolia, China

PLoS Negl Trop Dis. 2023 Mar 9;17(3):e0011121. doi: 10.1371/journal.pntd.0011121. eCollection 2023 Mar.

Abstract

Tick-borne infectious diseases pose a serious health threat in certain regions of the world. Emerging infectious diseases caused by novel tick-borne pathogens have been reported that are causing particular concern. Several tick-borne diseases often coexist in the same foci, and a single vector tick can transmit two or more pathogens at the same time, which greatly increases the probability of co-infection in host animals and humans and can lead to an epidemic of tick-borne disease. The lack of epidemiological data and information on the specific clinical symptoms related to co-infection with tick-borne pathogens means that it is not currently possible to accurately and rapidly distinguish between a single pathogen infection and co-infection with multiple pathogens, which can have serious consequences. Inner Mongolia in the north of China is endemic for tick-borne infectious diseases, especially in the eastern forest region. Previous studies have found that more than 10% of co-infections were in host-seeking ticks. However, the lack of data on the specific types of co-infection with pathogens makes clinical treatment difficult. In our study, we present data on the co-infection types and the differences in co-infection among different ecological regions through genetic analysis of tick samples collected throughout Inner Mongolia. Our findings may aid clinicians in the diagnosis of concomitant tick-borne infectious diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacteria / genetics
  • China / epidemiology
  • Coinfection* / epidemiology
  • Communicable Diseases, Emerging*
  • Humans
  • Tick-Borne Diseases* / epidemiology
  • Tick-Borne Diseases* / microbiology
  • Ticks* / microbiology

Grants and funding

The research was supported by the following grants: Science and Technology Program of Inner Mongolia (to Gaowa); The Natural Science Foundation of Inner Mongolia (No. 2021MS03029 to Wulantuya); Bayan Nur Doctoral Scientific Research Station (No. BKZ2016 to Gaowa); The Grassland Elite Program of Inner Mongolia (to Gaowa); The Hetao Elite Program of Bayan Nur (to Gaowa); Inner Mongolia Higher Education Science and Technology Research Project (No. NJZY21185 to DL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.