Increased risk of early-onset preeclampsia in pregnant women with COVID-19

Niraj N Mahajan; Shweta Kesarwani; Padmaja Kumbhar; Periyasamy Kuppusamy; Madhura Pophalkar; Pratiksha Thamke; Ruchi Asawa; Saumya Sharan; Smita D Mahale; Rahul K Gajbhiye

doi:10.1080/10641955.2023.2187630

Increased risk of early-onset preeclampsia in pregnant women with COVID-19

Hypertens Pregnancy. 2023 Dec;42(1):2187630. doi: 10.1080/10641955.2023.2187630.

Affiliations

¹ Department of Obstetrics and Gynecology, Topiwala National Medical College & BYL Nair Charitable Hospital, Mumbai, India.
² Clinical Research Laboratory, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India.
³ Emeritus Scientist, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai, India.

PMID: 36891839
DOI: 10.1080/10641955.2023.2187630

Abstract

Objective: To estimate incidence, risk of early and late-onset preeclampsia (PE) and understand their relationship with severity of COVID-19.

Methods: Pregnant women with COVID-19 (n = 1929) were enrolled from 1 April 2020 to 24 February 2022. Primary outcome measure was incidence and risk of early onset PE in women with COVID-19.

Results: The incidence of early and late-onset PE was 11.4% and 5.6%. Moderate to severe COVID-19 was associated with eight times higher risk of early onset PE [aOR = 8.13 (1.56-42.46), p = 0.0129] compared to asymptomatic group.

Conclusions: Risk of early onset PE was higher in pregnant women with symptomatic COVID-19 as compared to asymptomatic women.

Keywords: COVID-19; SARS-CoV-2 infection, second wave, third wave; early onset preeclampsia; first wave, late-onset preeclampsia.

MeSH terms

COVID-19* / complications
Female
Humans
Incidence
Pre-Eclampsia* / epidemiology
Pre-Eclampsia* / etiology
Pregnancy
Pregnancy Trimester, Third
Pregnant Women