A Large Contemporary Experience of Renal Tumors in Young: Clinico-pathological Profile and Long-Term Survival Patterns

Rishi Nayyar; Manish Khattar; Rohit Dadhwal; Prabhjot Singh; Brusabhanu Nayak; Rajeev Kumar; Amlesh Seth

doi:10.1007/s13193-022-01643-2

A Large Contemporary Experience of Renal Tumors in Young: Clinico-pathological Profile and Long-Term Survival Patterns

Indian J Surg Oncol. 2023 Mar;14(1):169-175. doi: 10.1007/s13193-022-01643-2. Epub 2022 Sep 10.

Authors

Rishi Nayyar¹, Manish Khattar¹, Rohit Dadhwal¹, Prabhjot Singh¹, Brusabhanu Nayak¹, Rajeev Kumar¹, Amlesh Seth¹

Affiliation

¹ Department of Urology, All India Institute of Medical Sciences, New Delhi, 110029 India.

Abstract

Renal tumors in young population are relatively rare. We reviewed our experience with renal masses in patients below 45 years of age. Our objective was to analyze clinico-pathological and survival characteristics of renal malignancy in young adults in contemporary era. The medical records of patients below 45 years of age who underwent surgery for renal mass at our tertiary care center between 2009 and 2019 were retrospectively analyzed. Pertinent clinical information was compiled, including age, gender, year and type of surgery, histopathology and survival data. A total of 194 patients who underwent nephrectomy for suspicious renal masses were included. Mean age was 35.5 (14-45) years and males were 125 (64.4%). A total of 29/198 (14.6%) specimens had benign disease. In addition, 155 (91.7%) out of 169 malignant tumors were renal cell carcinomas, clear cell variant being the most common type (51%). Compared to RCC, non-RCC tumors were more common in females (27.7 vs 78.6%, p < 0.0001), had an early age of diagnosis (27.2 vs 36.9 year, p < 0.00001) and poorer progression-free (58.3 vs 72.0%, p = 0.03) and overall survival (63.6 vs 84.2%, p = 0.02) at 6 years of follow-up. Renal masses in young adults are most commonly RCC but can also include other diverse types. RCC in young adults is usually organ confined and has good prognosis. As compared to RCC, non-RCC malignant tumors occur in young age, are more in females, and have worse prognosis.

Supplementary information: The online version contains supplementary material available at 10.1007/s13193-022-01643-2.

Keywords: Partial nephrectomy; Radical nephrectomy; Renal cell carcinoma; Survival; Variant histology; Young.

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