The role of bile acid in intestinal metaplasia

Menglei Wang; Enzhe Lou; Zengfu Xue

doi:10.3389/fphys.2023.1115250

The role of bile acid in intestinal metaplasia

Front Physiol. 2023 Feb 20:14:1115250. doi: 10.3389/fphys.2023.1115250. eCollection 2023.

Authors

Menglei Wang¹, Enzhe Lou¹, Zengfu Xue¹

Affiliation

¹ Department of Digestive Diseases, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.

Abstract

A precancerous lesion of gastric cancer (GC), intestinal metaplasia (IM) is a pathological transformation of non-intestinal epithelium into an intestinal-like mucosa. It greatly raises the risk of developing the intestinal type of GC, which is frequently observed in the stomach and esophagus. It is understood that esophageal adenocarcinoma's precursor lesion, chronic gastroesophageal reflux disease (GERD), is what causes Barrett's esophagus (BE), an acquired condition. Recently, Bile acids (BAs), which are one of the compositions of gastric and duodenal contents, have been confirmed that it led to the occurrence and development of BE and gastric intestinal metaplasia (GIM). The objective of the current review is to discuss the mechanism of IM induced by bile acids. This review serves as a foundation for further research aimed at improving the way BE and GIM are currently managed.

Keywords: Barrett’s esophagus (BE); bile acid; gastroesophageal reflux; intestinal metaplasia; molecular mechanism.

Publication types

Review

Grants and funding

This study was supported by the National Natural Science Foundation of China (grant no.81201674), National Key R&D Program of China (grant no. 2017YFC0908300), Natural Science Foundation of Fujian Province (grant no. 2022J011231).