Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia

ASN Neuro. 2023 Jan-Dec:15:17590914231158218. doi: 10.1177/17590914231158218.

Abstract

HIV/HIV-1 Tat and morphine independently increase pathologic phosphorylation of TAR DNA binding protein 43 in the striatum. HIV- and opioid-induced pathologic phosphorylation of TAR DNA binding protein 43 may involve enhanced CK2 activity and protein levels.

Keywords: CX-4945 (Silmitasertib); TDP-43 proteinopathy; casein kinase 2; inositol-triphosphate 3-kinase B; neuro-acquired human immunodeficiency syndrome (neuroHIV); opioid use disorder.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Analgesics, Opioid / metabolism
  • Analgesics, Opioid / pharmacology
  • Basal Ganglia / metabolism
  • Casein Kinase II / metabolism
  • DNA-Binding Proteins
  • HIV Infections*
  • HIV-1* / metabolism
  • Humans
  • Phosphorylation
  • Protein Binding
  • tat Gene Products, Human Immunodeficiency Virus / metabolism

Substances

  • Casein Kinase II
  • Analgesics, Opioid
  • tat Gene Products, Human Immunodeficiency Virus
  • DNA-Binding Proteins