Abstract
HIV/HIV-1 Tat and morphine independently increase pathologic phosphorylation of TAR DNA binding protein 43 in the striatum. HIV- and opioid-induced pathologic phosphorylation of TAR DNA binding protein 43 may involve enhanced CK2 activity and protein levels.
Keywords:
CX-4945 (Silmitasertib); TDP-43 proteinopathy; casein kinase 2; inositol-triphosphate 3-kinase B; neuro-acquired human immunodeficiency syndrome (neuroHIV); opioid use disorder.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Analgesics, Opioid / metabolism
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Analgesics, Opioid / pharmacology
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Basal Ganglia / metabolism
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Casein Kinase II / metabolism
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DNA-Binding Proteins
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HIV Infections*
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HIV-1* / metabolism
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Humans
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Phosphorylation
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Protein Binding
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tat Gene Products, Human Immunodeficiency Virus / metabolism
Substances
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Casein Kinase II
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Analgesics, Opioid
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tat Gene Products, Human Immunodeficiency Virus
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DNA-Binding Proteins