Translocation of health-promoting enzymes across the gut barrier

Abstract

Tiny amounts of exogenous enzymes entering the plasma can exert important health-promoting functions. We propose that orally administered enzymes can potentially translocate across the gut barrier to combat reduced fitness and diseases concurrent with increased gut permeability. Engineering of the enzymes using two discussed strategies may further improve their translocation efficiency.

Keywords: chronic diseases; gut barrier; health-promoting enzymes; translocation.