Rejuvenating muscle stem cells with the glutathione system

Laura Forcina; Antonio Musarò

doi:10.1016/j.cmet.2023.02.009

Rejuvenating muscle stem cells with the glutathione system

Cell Metab. 2023 Mar 7;35(3):379-381. doi: 10.1016/j.cmet.2023.02.009.

Authors

Laura Forcina¹, Antonio Musarò²

Affiliations

¹ DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory affiliated with Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Via A. Scarpa, 14 Rome 00161, Italy.
² DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Laboratory affiliated with Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Via A. Scarpa, 14 Rome 00161, Italy. Electronic address: antonio.musaro@uniroma1.it.

PMID: 36889277
DOI: 10.1016/j.cmet.2023.02.009

Abstract

Aging results from the combination of complex processes still largely undefined. In this issue, Benjamin et al. use multiomic analysis to reveal a causative role of altered glutathione (GSH) synthesis and metabolism in age-dependent muscle stem cell (MuSC) dysfunction, casting light on novel mechanisms regulating stem cell function and on therapeutic approaches to improve defective regeneration in the aged muscle.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Glutathione / metabolism
Muscle, Skeletal* / metabolism
Stem Cells* / metabolism

Substances

Glutathione