Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate

Kidney360. 2023 May 1;4(5):673-679. doi: 10.34067/KID.0000000000000099. Epub 2023 Mar 8.

Abstract

  1. Urinary TIMP2×IGFBP7 (uTIMP2×IGFBP7) concentrations experienced a rapid and sustained decline after high-dose methotrexate (MTX) exposure.

  2. uTIMP2×IGFBP7 kinetics and concentrations after high-dose MTX exposure demonstrated no utility in predicting AKI.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Insulin-Like Growth Factor Binding Proteins / metabolism
  • Kinetics
  • Matrix Metalloproteinase 2* / metabolism
  • Methotrexate* / adverse effects

Substances

  • Methotrexate
  • Matrix Metalloproteinase 2
  • Insulin-Like Growth Factor Binding Proteins