Purpose: To report an atypical case of bilateral syphilitic chorioretinitis.
Methods: A case report.
Results: A young male presented with bilateral pigmentary retinal changes along with multifocal chorioretinal lesions along the blood vessels giving a "beaded pearl" appearance. He was a hitherto undiagnosed case of human immunodeficiency virus infection and was diagnosed to have syphilis. He had a favourable visual and anatomical outcome following treatment.
Conclusion: Multifocal chorioretinal lesions along blood vessels forming a "beaded pearls" appearance can be a rare and unique presentation of syphilis.
Keywords: Acquired immunodeficiency syndrome; HIV; chorioretinitis; human immunodeficiency virus; nyctalopia; pigmentary retinopathy; posterior uveitis; syphilis; syphilitic chorioretinitis.