Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells

Elisabeth Meedt; Daniela Weber; Agnes Bonifacius; Britta Eiz-Vesper; Britta Maecker-Kolhoff; Susanne Delecluse; Henri-Jacques Delecluse; Myriam Lorenz; Klaus Schwarz; Stefan T Meedt; Jan Braess; Wolfgang Herr; Ernst Holler; Matthias Edinger; Daniel Wolff

doi:10.1093/cid/ciad131

Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells

Clin Infect Dis. 2023 Jun 16;76(12):2200-2202. doi: 10.1093/cid/ciad131.

Authors

Affiliations

¹ Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
² Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
³ Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
⁴ German Cancer Research Center (DKFZ), Unit F100, Heidelberg, Germany.
⁵ Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.
⁶ Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg-Hessen, Ulm, Germany.
⁷ Department of Hematology and Oncology, Krankenhaus Barmherzige Brüder, Regensburg, Germany.

PMID: 36883586
DOI: 10.1093/cid/ciad131

Abstract

We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.

Keywords: CAEBV; EBV-specific T cells; allogeneic stem cell transplantation; anti-T-lymphocyte globulin.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Epstein-Barr Virus Infections* / therapy
Female
Graft vs Host Disease*
Hematopoietic Stem Cell Transplantation* / adverse effects
Herpesvirus 4, Human
Humans
T-Lymphocytes
Transplantation, Homologous / adverse effects