Features of the Free Radical Oxidation Process and Antioxidant System in Newborns Born to HIV-Infected of Mothers Who Received Antiretroviral Therapies to Prevent HIV Transmission

Bull Exp Biol Med. 2023 Feb;174(4):413-416. doi: 10.1007/s10517-023-05719-z. Epub 2023 Mar 7.

Abstract

The LPO processes and the state of the antioxidant system in perinatally HIV-exposed newborns were studied. Perinatally HIV-exposed (n=62) and healthy newborns (n=80; control) were examined retrospectively (Apgar score 8 in both groups). Blood plasma and erythrocyte hemolysate were used as the material for biochemical tests. Using spectrophotometric, fluorometric, and statistical methods, we found enhanced LPO processes insufficiently compensated by the antioxidant system with excessive accumulation of damaging metabolites in the blood of perinatally HIV-exposed newborns. These changes can be a consequence of oxidative stress during the perinatal period.

Keywords: LPO; antioxidant defense system; perinatally HIV-exposed newborns.

MeSH terms

  • Antioxidants / therapeutic use
  • Female
  • Free Radicals
  • HIV Infections* / drug therapy
  • HIV Infections* / prevention & control
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / prevention & control
  • Pregnancy
  • Pregnancy Complications, Infectious* / drug therapy
  • Retrospective Studies

Substances

  • Antioxidants
  • Free Radicals