Copper-catalyzed selective alkynylation with N-propargyl carboxamides as nucleophiles has been successfully developed for the synthesis of C2-functionalized chromanones. Under optimized reaction conditions, 21 examples were obtained in one-pot procedure through 1,4-conjugate addition. This protocol features readily available feedstocks, easy operations, and moderate to good yields, which provides viable access to pharmacologically active C2-functionalized chromanones.
Keywords: 1,4-Conjugate addition; Alkynylation; C2-functionalized chromanones; Copper-catalyzed; One-pot.
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.