Association of the time in targeted blood glucose range of 3.9-10 mmol/L with the mortality of critically ill patients with or without diabetes

Guo Yu; Haoming Ma; Weitao Lv; Peiru Zhou; Cuiqing Liu

doi:10.1016/j.heliyon.2023.e13662

Association of the time in targeted blood glucose range of 3.9-10 mmol/L with the mortality of critically ill patients with or without diabetes

Heliyon. 2023 Feb 11;9(3):e13662. doi: 10.1016/j.heliyon.2023.e13662. eCollection 2023 Mar.

Authors

Guo Yu¹, Haoming Ma¹, Weitao Lv², Peiru Zhou³, Cuiqing Liu²

Affiliations

¹ School of Nursing, Jinan University, No. 601, West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province, China.
² Division of Critical Care, The First Affiliated Hospital of Jinan, No. 613, West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province, China.
³ Health Management Centre, The Fifth Affiliated Hospital of Jinan, South Yingke Avenue, Jiangdong New District, Heyuan City, Guangdong Province, China.

Abstract

Purpose: The relationship between the TIR and mortality may be influenced by the presence of diabetes and other glycemic indicators. The purpose of this study was to investigate the relationship between TIR and in-hospital mortality in diabetic and non-diabetic patients in ICU.

Methods: A total of 998 patients with severe diseases in the ICU were selected for this retrospective analysis. The TIR is defined as the percentage of time spent in the target blood glucose range of 3.9-10.0 mmol/L within 24 h. The relationship between TIR and in-hospital mortality in diabetic and non-diabetic patients was analyzed. The effect of glycemic variability was also analyzed.

Results: The binary logistic regression model showed that there was a significant association between the TIR and the in-hospital death of severely ill non-diabetic patients. Furthermore, TIR≥70% was significantly associated with in-hospital death (OR = 0.581, P = 0.003). The study found that the coefficient of variation (CV) was significantly associated with the mortality of severely ill diabetic patients (OR = 1.042, P = 0.027).

Conclusions: Both diabetic and non-diabetic critically ill patients should control blood glucose fluctuations and maintain blood glucose levels within the target range, it may be beneficial in reducing mortality.

Keywords: Blood glucose control; Diabetes; Glycemic variability; Mortality; Severe disease; Time in targeted blood glucose range.