Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report

Amaranto Suárez; Nathalie Soler; Alejandra Calderon; Bibiana Martinez; Martha Piña

doi:10.7759/cureus.34549

Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report

Cureus. 2023 Feb 2;15(2):e34549. doi: 10.7759/cureus.34549. eCollection 2023 Feb.

Authors

Amaranto Suárez¹, Nathalie Soler², Alejandra Calderon², Bibiana Martinez³, Martha Piña²

Affiliations

¹ Pediatric Oncology, Instituto Nacional de Cancerología, Bogotá, COL.
² Pediatric Oncology, Instituto Nacional de Cancerología, Bogota, COL.
³ Bacteriologist, specialising in Haematology, Instituto Nacional de Cancerología, Bogota, COL.

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive malignancy with high mortality involving the skin and hematopoietic system. Clinical suspicion is difficult, and management of skin lesions is challenging due to their indolent course prior to dissemination. We describe a patient with isolated skin involvement who progressed to CD4+/CD56+ and CD123+ acute leukemia.

Keywords: blastic plasmacytoid dendritic cell neoplasm; clinics; leukemia; morphology; pediatric.

Publication types

Case Reports